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 УЧРЕДИТЕЛИ:
Федеральное государственное бюджетное учреждение науки
"Институт токсикологии Федерального медико-биологического агентства"
(ФГБУН ИТ ФМБА России)

Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН".




Адрес редакции и реквизиты

199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система
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«
Vol. 13, Art. 34 (pp. 408-432)    |    2012       
»

The human aorta cellular network and maintenance of vascular homeostasis
Y.V.Bobryshev, V.P.Karagodin, M.M. Moysenovich, M.A.Gavrilin, A.А. Melnichenko, V.А. Оrekhova, E.N. Borodachev, I.A. Sobenin, А.N.Оrekhov

1Institute for Atherosclerosis Research, Skolkovo Innovative Center, 143025, 100 Novaya Str., Moscow, Russia

2 Institute of General Pathology and Pathophysiology: 8 Baltiyskaya Str., 125315, Moscow, Russia.



Brief summary

The architectonics and cell composition of the human large arteries are not sufficiently understood. The present study is the first to undertake an analysis of the distribution and quantities of HLA-DR-expressing cells in grossly undiseased human intima using immunohistochemical and immunofluorescent analysis, complemented by the advantages of confocal microscopy. The study revealed a widespread distribution of HLA-DR-expressing cells throughout the intimal space where the cells were integrated into continuous networks via long cell processes. Numbers of HLA-DR+ cells were found to be significantly larger in the middle third of the intima than in the superficial and deep intimal portions. We speculate that a widespread distribution of HLA-DR-expressing cells in the intima of normal human aorta might play a role in the surveillance and maintenance of vascular homeostasis.


Key words

aorta; intima; HLA-DR; atherosclerosis





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