The effectiveness of applying dexamethasone in order to eliminate glucose malabsorption produced by acute T-2 toxicosis
Skalich I.P.*, Zhukov V.E.
Research Institute of Hygiene, Toxicology and Occupational Pathology of Federal Medical and Biological Agency of Russia
The aim of this study was to investigate the possibility of applying dexamethasone for prevention and treatment purposes to eliminate glucose malabsorption produced by acute T-2 toxicosis in white outbred rats. T-2 toxin was administered intragastrically at a dose level of 1/2 DL50 (1.4 mg/kg), dexamethasone - intramuscularly at a level of 0.02 mg/kg. Glucocorticoid was injected 30 minutes before the exposure or 30 minutes and 3 hours after the intoxication. It was revealed that T-2 toxin inhibited glucose absorption by 30.0%. A dexamethasone administration stimulated glucose penetration through the apical membrane of the enterocyte undependent on the time while maximum stimulation glucose penetration (by 220.0% ) was registered for prevention administration of the hormone.