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Vol. 12, Art. 95 (pp. 1169-1179)    |    2011       

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Comparable evaluation of different methods of extracorporeal detoxication in acute carbamazepine poisoning

Maslov OG, Brusin KM, Kochmashev VF, Sentsov VG.

The Ural State Medical Academy.

The Ural State Pedagogical University.

Brief summary

Effectiveness of hemoperfusion and hemodialysis was evaluated in acute carbamazepine poisoning. Hemoperfusion was used in 21 cases (VNIITU and Adsorba-300 columns), hemodialysis was used in 13 cases. Carbamazepine hemoperfusion clearance was significantly higer than hemodialysis one. But carbamazepine blood level was significantly lower after hemodialysis than after VNIITU hemoperfusion and was not significantly lower after hemodialysis than after Adsorba-300 hemoperfusion. The average carbamazepine half-time was 3.3±1.7 hours during VNIITU hemoperfusion, 12.3±3.2 hours during Adsorba-300 hemoperfusion and 11.3±1.3 hours during hemodialysis. Six hours hemodialysis had the same effectiveness that 3-hours Adsorba-300 hemoperfusion but was 3 times cheaper.


Key words

Poisoning, carbamazepine, hemoperfusion, hemodialysis, extracorporeal detoxication.

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