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Vol. 12, Art. 94 (pp. 1156-1168)    |    2011       

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The investigated chemotherapy effects of immunologic impairments and quality of life in patients with malignant lymphomas

A.V. Novitskiy1, Yu.A. Sukhonos1, A.S.Povzun2, A.M. Ivanov1, Yu.S. Khalimov1, Yu.M. Atyunin3, A.K. Yurkin1, A.V. Fomichev1, V.A. Sidorenko4
1 Military Medical Academy n.a. S.M. Kirov, Saint-Petersburg;

2 Scientific Research Institute of Emergency Care n.a. I.I. Dzhanelidze, Saint-Petersburg;

3 Department of Medical Care of Saint-Petersburg;

4 The Medical sanitary of the Ministry of internal affairs of the Russian Federation of
Saint-Petersburg and Leningrad region

Brief summary

The criteria of immunotherapy effectiveness in malignant lymphomas patients were investigated. The most distinguish diagnostic criteria of immune and quality of life impairments to individualize pharmacologic therapy malignant lymphomas patients were found out. The treatment strategy for a malignant lymphomas patients with immunodeficiency and a low quality of life score was defined.


Key words

malignant lymphomas, immunodeficiency, quality of life, chemotherapy

Reference list

1. Mazyrov V.I. Obshie i chastnie zakonomernosti izmenenii v immynitete y bolnih limfoproliferativnimi i aytoimmynnimi zabolevaniyami / V.I. Mazyrov, A.M. Lila, K.V. Raimyev // Med. immynologiya. – 2002. – T. 4, №2. – S. 204.


2. Novickii A.V. Prognosticheskoe znachenie obshego kachestva jizni y bolnih zlokachestvennimi limfomami / A.V. Novickii, U.A. Syhonos, S.V. Petlenko // Ros. biomed. jyrn. Medlain.Ry. – 2009. – T. 10. – St. 12. – S. 168– 187.


3. Aldinucci D. The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape / D. Aldinucci // J. Pathol. – 2010. – Vol. 221, № 3. – P. 248–263.


4. Armitage J.O. Early-stage Hodgkin's lymphoma / J.O. Armitage // N. Engl. J. Med. – 2010. – Vol. 363, № 7. – P. 653–662.


5. Hirohashi Y. Immune response against tumor antigens expressed on human cancer stem-like cells/tumor-initiating cells / Y. Hirohashi // Immunotherapy. – 2010. – Vol. 2, № 2. – P. 201–211.


6. Hsi E.D. Biologic features of Hodgkin lymphoma and the development of biologic prognostic factors in Hodgkin lymphoma: tumor and microenvironment / E.D. His // Leuk. Lymphoma. – 2008. – Vol. 49, № 9. – P. 1668–1680.


7. Hudnall S.D. Comparative flow immunophenotypic features of the inflammatory infiltrates of Hodgkin lymphoma and lymphoid hyperplasia / S.D. Hudnall // Cytometry B. Clin. Cytom. – 2008. – Vol. 74, № 1. – P. 1–8.


8. Kppers R. The biology of Hodgkin’s lymphoma / R. Kppers // Nat. Rev. Cancer. – 2009b. – Vol. 9. – P. 15–27.


9. Leandro M.J. Anti-tumour necrosis factor therapy and B cells in rheumatoid arthritis / M.J. Leandro // Arthritis Res. Ther. – 2009. – Vol. 11, № 5. – P. 128.


10. Sukhonos Yu. Quality of life of the healthy population of St. Petersburg / Yu. Sukhonos, A. Novik, T. Ionova // Quality of Life Research. – 2000. – Vol.9, ¹ 3. – P. 308.


11. Ware J.E. Overwiev of the SF-36 Health Survey and the IQUOLA Project / J.E. Ware, B. Gandek // J. Clin. Epid. – 1998. – Vol. 51, ¹11. – P. 903–912.