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Vol. 12, Art. 87 (pp. 1067-1091)    |    2011       

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Serum albumin: Structure and carrying function (Review)

Pshenkina N.N.

Military Medical Academy named after S.M. Kirov,
Academic Lebedev str., 6, Saint Petersburg, 194044, Russia

Brief summary

Modern advances in research of structure and function of human serum albumin relating to drug carrying are reviewed. The main drugs' binding sites are characterized. Regulation of drug binding and dissociation of ligand-protein complexes during drugs’ transfer to tissues are considered. In conclusion, prospective areas of further investigations of albumin structure and functions are proposed and possible ways of practical application are considered as well.


Key words

albumin, structure, binding, drug delivery, drugs, fatty acids.

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