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Vol. 12, Art. 82 (pp. 990-1013)    |    2011       

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Oxygen carrying hemoglobin-based blood substitutes

Selivanov E.A.1, Pshenkina N.N.2, Murzina E.V.2, Sofronov G.A.2,
Khanevich M.D.2, Sarychev V.A.3

1- Russian Research Institute for Hematology and Transfusiology of Health Ministry of Russian Federation, 2 Sovetskaya, 16, Saint Petersburg, 191024

2- Military Medical Academy named after S.M. Kirov, Academic Lebedev str., 6,
Saint Petersburg, 194044

3- Gelenpol, Ltd., Marx pr., 14, Obninsk, Kaluga region, 249035

Brief summary

Substantial efforts to develop a blood substitutes on the base of modified hemoglobin have been made since the end of last century. The review reflects main achievements and complications on the way of development of hemoglobin-based oxygen carriers.


Key words

hemoglobin, oxygen-carrying blood substitutes, preclinical and clinical trials, adverse effects.

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