Russian Research Center for Radiology and Surgical Technologies Federal Agency of High Medical Care Technology
Purpose: The evaluation of efficacy of proton «hypophysectomy» in patients with locallyadvanced and disseminated prostate cancer.
Material and Methods: 98 patients with disseminated prostate cancer and suffered from the pain had been irradiating on the synchrocyclotron PNPI (1000 MeV, Gatchina). The irradiation by rotating-convergent shoot-through technique had been using. The single dose of 80-100 Gy had been giving. The grade of pain syndrome had been evaluated before and after proton therapy by four-grade scale.
Results: The results are evidence of high efficacy of the proton therapy as an pain relieving method: 53 (66.25%) of patients have a complete analgesia, and 22 (27,5%) have a significant pain relief. Bone metastases in 3 (3%) patients have disappeared, in 8 (8%) there was a partial regress of bone lesions and in 3 (3%) the transformation of osteolytic lesions to osteosclerotic was occur.
Conclusion: Proton «hypophysectomy» is an effective method of pain relief in patients with metastatic prostate cancer without evident complications and is of great importance for palliative care of such patients.
1. Foley K.M: The treatment of cancer pain. N Engl J Med, 1985, Vol.313,-P.84–95.
2. Hayashi M, Taira T, Chernov M, Fukuoka S, Liscak R, Chung Ping Yu, Ho R.T.K, Regis J, Katayama Y, Kawakami Y, Hori T. Gamma knife surgery for cancer pain–pituitary gland–stalk ablation: a multicenter prospective protocol since 2002.- J Neurosurg , 2002 (Suppl 5) Vol 97, -P. 433–437.