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Vol. 12, Art. 38 (pp. 458-463)    |    2011       

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Influence of triazavirin on enzymes of detoxication activity

Cherkashchenko O.S.

Northwest Public Health Research Center, Saint-Petersburg, The 2 Sovetskaya

Brief summary

The article presents the materials of toxicological studies about the influence of a new drug triazavirin used for influenza treatment on the detoxication liver function. The following facts are proved that the test drug inhibits the activity of enzymes of hepatocytes’ endoplasmic reticulum, and therefore can lead to a damage of the detoxication liver function.


Key words

triazavirin, enzymes, endoplasmic reticulum, hepatocytes, detoxication.

Reference list

1. Lyahovich V.V., Cirlov I.B. Indykciya fermentov metabolizma ksenobiotikov. Novosibirsk: Nayka. - 1985. - 240 s.


2. Tiynov L.A. Osnovnie mehanizmi metabolizma ksenobiotikov v organizme che- loveka i jivotnih // Itogi nayki i tehniki VINITI (toksikologiya). – 1981. - №12. – s.5-64


3. Sidorin G.I. K voprosy o biohimicheskoi adaptacii pri ekstremalnom i hro- nicheskom deistvii promishlennih yadov.// Sovremennie problemi profilakticheskoi toksikologii / Moskovskii NII gigieni im. F.F. Erismana. – M., 1991. – S.4-25.


4. Popov T.A., Leonenko O.B. O vozmojnosti ocenki aktivnosti mikrosomalnih oksidaz smeshannoi fynkcii pecheni v dinamike. – V kn.: Matematicheskie modeli v bio- logii i issledovanie fiziologicheskih sistem. Kiev. – 1975. - S.100-103.


5. Gybler E.V. Primenenie neparametricheskih kriteriev statistiki v mediko- biologicheskih issledovaniyah / E.V. Gybler, A.A. Genkin. – L. : Medicina, 1973. – 144 s.


6. Kykes V.G., Grachyov S.V., Sichyov D.A., Ramenskaya G.V. Metabolizm lekarstvennih sredstv. Naychnie osnovi personalizirovannoi medicini: rykovodstvo dlya vrachei. – M.: GEOTAR. – Media. – 2008. – 304 s.