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"Институт токсикологии Федерального медико-биологического агентства"
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Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН".




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199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система
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«
Vol. 12, Art. 36 (pp. 431-447)    |    2011       
»

Modern aspects of pathogenesis of benign and dysplastic cervical diseases (review)
Evtina IP 1, Sidorova IS 1, Unanian AL 1, Vlasov R.S.1, Kadirova A.E.1, Karpov D.V.1

1 - Department of Obstetrics and Gynecology, a LF (Head - Corresponding Member. Academy of Medical Sciences, prof. I.S. Sidorova) First MGMU



Brief summary

Pathological processes in cervix uteri are among the pressing issues of modern gynecology due to the fact they are often transformed into malignant processes and are often detected in the reproductive age. Benign diseases are not the cause of tumor development, however they often precede dysplastic processes. Among the important factors necessary for the tumor growth development are epigenetic disturbances, which include methylation of tumor (growth) suppressor genes. Comprehensive assessment of clinically specific peculiarities of benign and precancerous processes in the cervix together with the results of studies of gene methylation will enable to work out the principles to predict the risk of malignant cervical pathology.


Key words

cervix uteri, benign and precancerous processes, human papilloma virus, methylation of genes.





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