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Vol. 11, Art. 59 (pp. 718-735)    |    2010       

№ гос. регистрации: 0421000002059

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Algorithm of exaperimental modelling of the toxic coma at rats

Bonitenko E.Yu., Golovko A.I., Basharin V.A., Ivanov M.B., Petrov A.H., Makarova N.V.

Federal State Scientific Institution «Institute of Toxicology» Federal Medico-Biological Agency, St. Petersburg, Russia

Brief summary

The algorithm of experimental models creation of coma at deprimative agents intoxications with the different mechanisms of toxic action is represented. Assessment criteria of the neurological functions oppression severity, the degree of coma depth and outcome prediction of acute poisoning with ethanol, 1,4-butanediol, sodium thiopental and sodium oxybutyrate are developed. Model of toxic coma can be created for certain substances in the experiment.


Key words

toxic coma, experimental model, intoxication

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