STRUCTURE AND FUNCTION OF KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTORS IN HEALTH AND DISEASE
Sokolova J.V., Bubnova L.N., Bessmeltsev S.S.
“Russian Research Institute of Hematology and Transfusiology”, Russian Federal MedicobiologicalAgency, St.-Petersburg, 191024, 2nd Sovietskaya str., 16.
The killer cell immunoglobulin-like receptors (KIR) play a crucial role in regulation of cytolytic activity of natural killer cells. KIR generate diversity at multiple levels: variability in the gene content, allelic polymorphism and clonal expression. HLA class I molecules serve as ligands for the KIR. KIR and HLA are located on different chromosomes and inherited independently. KIR-genes polymorphism and combinations of HLA class I and KIR variants play an important role in susceptibility or resistance to infectious diseases, autoimmune disorders and malignancies.
killer cell immunoglobulin-like receptors, KIR gene, KIR receptor, HLA ligand, natural killer, HLA system.