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Vol. 11, Art. 52 (pp. 611-634)    |    2010       

№ гос. регистрации: 0421000002052

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SOME MECHANISMS OF BIOENERGY DISORDERS AND OPTIMIZATION OF THE APPROACHES TO ITS PHARMACOTHERAPY

Federal State Scientific Institution «Institute of Toxicology» Federal Medico-Biological Agency, St. Petersburg, Russia

Brief summary

Kashuro V.A., Dolgo-Saburov V.B., Basharin V.A., Bonitenko E.Yu., Lapina N.V. The molecular mechanisms of energy supply disorders in the cells during hypoxia are considered. Deficiency of oxidized form NAD and increase NADН/NAD ratio lead to disruptions such as disorders of glycolysis, citric acid cycle, exchange of lipids and amino acids, activation of free-radical processes and apoptosis. The main directions of energy metabolism support therapy during hypoxia are formulated.


Key words

hypoxia, bioenergy metabolism, pharmacotherapy, mitochondria.

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