Components of the innate immune response in development of cirrhosis in patients with chronic hepatitis C
A.O. Romanov, T.V. Belyaeva, E.V. Esaulenko
St. Petersburg State Medical University. Acad. I.P. Pavlova
Chronic injury in response to persistent HCV replication leads to liver fibrosis. Ribonuclease L and mannose-binding lectin are critical components of the innate immune response to viruses. Functional polymorphisms in these genes could be associated with variability in the progression of HCV-related cirrhosis. The distribution of +1385G/A RNASEL and +230G/A MBL gene polymorphisms were analyzed by polymerase chain reaction restriction fragment length polymorphisms to evaluate whether these polymorphisms are associated with the natural outcome of hepatitis C virus infection. For patients with chronic hepatitis C, combinations of the variant genotypes of +1385G/A RNASEL and +230G/A MBL could increase the risk of developing cirrhosis.