1- City Hospital № 33 named. prof. AA Ostroumov Department of Health, Moscow (107014, Moscow, st. Strominka d.7)
2- National Institute of Advanced Medical Defense Ministry (109545, Moscow, st. MG Cherkizovskaya, 7)
Summary: 221 patients were investigated on endotoxicosis with the diagnosis of a criminal poisoning by clozapine. It is established that ammonia of plasma’s blood is the earliest and informative indicator of endotoxicosis, concentration by which increases with severity of a chemical trauma in 1,2-2,1 times (р<0,05). The treatment with hypoammoniemic drug amino acid - L-ornitin, L-aspartat («Hepa-Merz») is accompanied by authentic reducing of treatment terms for patients and normalizing of psycho physiological conditions in earlier terms.