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 УЧРЕДИТЕЛИ:
Федеральное государственное бюджетное учреждение науки
"Институт токсикологии Федерального медико-биологического агентства"
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Институт теоретической и экспериментальной биофизики Российской академии наук.

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199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

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«
Vol. 11, Art. 13 (pp. 147-159)    |    2010       
»

Expression of melatonin receptor genes in planarians schmidtea mediterranea and their possible role in the processes of proliferation and differentiation of stem cells
Ermakova O.N., Ermakov A.M., Evdokimovsky E.V.



Brief summary

Investigation of melatonin membrane receptors expression in planarians Schmidtea mediterranea revealed that melatonin receptor orthologs Smed-mt 1, Smed-mt 2 и Smed-mel 1c are highly expressed in the head area whereas in the tail region their expression is minimal. Regeneration of dissected head and tail parts in planarians was accompanied by a decrease of expression level of all three type melatonin receptors. RNA interference of melatonin receptor Smed-mt 2 caused defects in process of head regeneration. The data obtained could explain the distoproximal inhibitory effect of melatonin on planarian regeneration and shed light on a new role of melatonin and its receptors as regulators of planarian regeneration and morphogenesis.We investigated 117 depressive patients using several neuroimaging methods. We found functional and structural abnormalities in limbic structures ingressed to the cortico-strio- thalamic-cortical neural circles within the all groups of patients. Functional neuroimaging methods (functional magnetic resonance imaging, positron emission tomography), basically, allow to reveal neuroimaging features at "neurotic" and "endogenous" depressions, in the form of various reaction patterns to emotionally-provocative stimulus (functional magnetic resonance imaging) and metabolism changes 18F-deoxyglucose (positron emission tomography). Structural neuroimaging methods (voxel-based morphometry, diffusion-tensor imaging) in more extent reflect morphofunctional features of "organic" depression in the form of grey substance density and anisotropy fraction change.


Key words

planarian, melatonin receptors, expression, regeneration, stem cells.





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Reference list

1. Pandi-Perumal S.R., Srinivasan V., Maestroni G.J.M., Cardinali G.P., Poeggeler B. Hardeland R. Melatonin. Nature’s most versatile biological signal? FEBS Journal, 2006, V. 273, P. 2813–2838.


2. Maharaj D.S, Glass B.D., Daya S. Melatonin: New Places in Therapy. Biosci. Rep, 2007, V. 27, P. 299–320.


3. Dubocovich M.L., Cardinali D.P., Delagrange P., Krause D.N., Strosberg D., Sugden D., Yocca F.D. Melatonin receptors. In The IUPHAR Compendium of Receptor Characterization and Classification, 2nd edn. (IUPHAR, ed.), 2000, P. 271–277. IUPHAR Media, London.


4. Ebisawa T., Karne S., Lerner M.R., Reppert S.M. Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophores. Proc. Natl. Acad. Sci. USA, 1994, V. 91, P. 6133–6137.


5. Dubocovich M.L., Markowska M. Functional MT1 and MT2 melatonin receptors in mammals. Endocrine, 2005, V. 27, P. 101–110.


6. Boutin J. A., Audinot V., Ferry G., Delagrange P. Molecular tools to study melatonin pathways and actions. Trends Pharmacol Sci, 2005, V. 26, P. 412-419.


7. Becker-Andre M., Wiesenberg I., Schaeren-Wiemers N., Andre E., Missbach M., Saurat J.H., Carlberg C. Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily. J. Biol. Chem, 1994, V. 269, P. 28531–28534.


8. Morita M., Hall F., Best J.B., Gem W. Photoperiodic modulation of cephalic melatonin in planarians. J. Exp. Zool, 1987, V. 214, P. 383-388.


9. Itoh M.T., Shinozawa T., Sumi Y. Cicadian rhythms of melatonin-synthesizing enzyme activities and melatonin levels in planarians. Brain Res, 1999, V. 830, P. 165–173.


10. Morita M., Best J.B. Effect of photoperiods and melatonin on planarian asexual reproduction. J. Exp. Zool, 1984, V. 231, P. 273-282.


11. Yoshizawa Y., Wakabayashi K., Shinozawa T. Inhibition of planarian regeneration by melatonin. Hydrobiologia, 1991, V. 227, P. 31-40.


12. Reddien P.W., Oviedo N.J., Jennings J.R., Jenkin J.C., Sanchez Alvarado A. SMEDWI-2 is a PIWI like protein that regulates planarian stem cells. Science, 2005, Vol. 310, P. 1327–1330.


13. Robb S.M., Ross E., Sanchez Alvarado A. Smedgd: the Schmidtea mediterranea genome database. Nucleic Acids Res, 2008, V. 36, P. D599-606.


14. Reddien P.W., Newmark P., Sánchez Alvarado A. Gene nomenclature guidelines for the planarian Schmidtea mediterranea. Dev. Dyn, 2008, V. 237, P. 3099–3101.


15. Newmark P., Sánchez Alvarado A. Bromodeoxyuridine specifically labels the regenerative stem cells of planarians. Dev. Bio, 2000, V. 220, P. 142-153.


16. Ermakova O.N., Ermakov A.M., Tiras H.P. Vliyanie melatonina na regeneraciu planarii Girardia tigrina. Ontogenez, 2009, №6, s.466-469.


17. Cos S., Sanchez-Barcelo E.J. Melatonin and mammary pathological growth. Front. Neuroendocrin, 2000, V. 17, P. 133-170.


18. Vieira De Souza A, Visconti M.A., De Lauro Castrucci A.M. Melatonin biological activity and binding sites in human melanoma cells. J. Pineal Res, 2003, V. 34, P. 242–248.


19. Kobayashi Y., Itoh M.T., Kondo H. Melatonin binding sites in estrogen receptor-positive cells derived from human endometrial cancer. J. Pineal Res, 2003, V. 35, P. 71–74.


20. Pellettieri J., Sanchez Alvarado A. Cell turnover and adult tissue homeostasis: from humans to planarians. Annu. Rev. Genet, 2007, V. 41, P. 83–105.


21. Orii H., Kato K., Umesono Y., Sakurai T., Agata K., Watanabe K. The planarian HOM/HOX homeobox henes (Plox) expressed along the anteroposterior axis. Dev. Biol, 1999 V. 210, P. 456 468.


22. Bueno D., Vispo M., Sancho V., Romero R. Maintenance of AP body regions in planarians by TCEN49, a putative cystine-knot neurotrophin. Bel. J. Zool, 2001, V. 131(Sppl.), P. 89-95.



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